Wow. I mean, wow. I was googling some flu information, and one of the first hits was so fundamentally wrong about all matters medical that I actually felt ill. (OK, maybe the “ill” part is the damned antibiotics, or the steroids, or something, but it definitely pissed me off.) This is from some cult medicine site called “Natural News” whose purpose is presumably commercial. The dangerous title is “Building a Child’s Immunity the Natural Way“. It’s wasn’t clear to me what this meant, so I had to read the damned thing. It starts out pretty bad…
New Jersey’s Public Health Council gave its citizens a Christmas present that will not please the health-conscious, as it became the first state in the nation to require flu shots for preschoolers.
So, if your “health-conscious”, you are against mandatory vaccination. Hmm…
Vaccines are dangerous for the health of any individual, but when administered to small children in their important developmental years, they are especially damaging. Medical “experts” have not even determined the correct dosages for small children, who in this regard are not just small adults. When we talk about daycare, we are talking about babies as young as a few months of age. Additionally, not only do vaccines usually contain mercury, but many lack effectiveness and can cause problems with the development of the child’s natural immune system (emphasis mine).
Look, I’m not going to address all of the anti-vaccination canards present in this piece, other than refer you to other excellent sources. Two things really get me though: lies, and this “immunity” thing.
Even if the evidence of a relationship between vaccine use and autism is disregarded, there are more debilitating results of vaccine administration to children. Due to the availability of new health information, a growing number of scientists and doctors have realized the problems revealed by recent immunology research and have begun to challenge the foundational tenets of vaccination. Because it seems that vaccines have eradicated many diseases in the last 100 years, many doctors have been reticent to question them. Such claims have mainly been based on epidemic studies rather than on clinical evidence.
For example, Europe never used the polio vaccines, yet it experienced the same rise and fall of polio cases as did the U.S.
That, my dear reader, is a lie. OK, if you are being generous, it is just ignorance, but I find it hard to be generous, given a 3 second stop at google will take you over to the World Health Organization and explain its polio eradication campaign in Europe. After a lie like that, it’s hard to believe anything that follows.
Also, many diseases that were believed to be wiped out have re-appeared under different names. As an example, spinal meningitis and polio have almost the same exact symptoms. There have never been any studies that proved the vaccines actually did cause the eradication of any disease; it has only been assumed by the fact that that the epidemics seemed to have ceased. The CDC uses the concept that a relationship does not prove causality to downplay the autism-thimerosal link, yet ironically, they don’t apply the same standard to the relationship between vaccination usage and the end of an epidemic.
That isn’t just “moving the goalposts“; that’s digging them up, burning them, and scattering the ashes. We all know epidemiologic studies have their limitations, but it’s pretty clear to the scientific community, beyond a reasonable doubt, that vaccines successfully prevent disease. (By the way, “spinal meningitis” and polio are completely unalike, and, believe it or not, we actually have tests to tell us what organism is causing an infection. Welcome to the early 20th century!)
All vaccines depress our immune functions. The chemicals in the vaccines depress our immune system; the virus present depresses immune function; and the foreign DNA/RNA from animal tissues depresses immunity. Studies have found that some metabolic functions were significantly reduced after vaccinations were given and did not return to normal for months. Other indicators of immune system depression included reduced lymphocyte viability, neutrophil hyper-segmentation, and a reduced white cell count. So we are trading a small immune depression for immunity to one disease, our only defense against all known disease for a temporary immunity against one disease, usually an innocuous childhood disease. Vaccines have been linked to AIDS and other immunodeficient disorders as well. The trade-off is not at all fair and not worth the risk.
Wow. This is so damned stupid. And dangerous. First, what does this phrase “immune depression” mean? I don’t know. They do give a hint futher down, throwing around big words like “neutrophil hypersegmentation” but that’s pretty meaningless as an observation, and without references is completely useless. Then the nice scare tactic of vaccines and AIDS. Nice. Really nice. OK, time to explain how vaccines actually work.
Vaccines and the Immune System
This is really cool…much cooler than the cultists would like you to believe. It is teh über-kool. And please forgive the over-simplification.
We need an example: let’s take polio vaccine—you know, the one they never used in Europe when the WHO wiped out polio in Europe. We have two choices, but the one we use the most in N.A. and Europe is the inactivated polio vaccine (IPV). Both of the polio vaccines have advantages and disadvantages, but hey, I only have so much time.
To make IPV, polio viruses are grown in the lab, then “inactivated” with a chemical. This renders them non-infectious. Then they are injected under the skin, which is where the fun starts.
When the inactivated viruses enter the tissues, immune cells patrolling the area detect foreign chemicals, usually proteins. (Viruses are not living organisms, but basically little bits of RNA or DNA and protein.) These cells engulf the invading viruses, process the parts, and actually display them on their surface, like a sign. Other cells (T-cells) come by, and if any of them happens to be able to read this sign, they get very excited. These cells, by various mechanisms, pass the news of the specific invader on to B-cells, which then mature and start making antibodies that are specific to the polio virus. This takes a few weeks. After this initial introduction of polio to the immune system, the antibody reaction dies down, and a few of these now-polio-specific B-cells go into hibernation in the spleen, lymph nodes, gut, and other nooks and crannies.
Let’s fast forward a few years. You are about to go on your dream vacation to Uganda. You’ve been warned about sporatic cases of polio in the area. You have every intention of avoiding unpurified water and uncooked foods, but nobody’s perfect. One night at dinner you accidentally eat the salad. They guy who made the salad just returned from the outhouse, which doesn’t have a sink. Eww. In his stool were some polioviruses. These were deposited on his hands, then into your salad, and ultimately into your gut. I hope it was a good salad.
When the virus reaches the gut, it latches onto the intestine. Some of your immune cells recognize it, and start the same process that happened when you were vaccinated. Except you have those clever little “memory B-cells” left over from your vaccination, so instead of the immune reaction taking weeks to ramp up, it takes hours. Your B-cells start dividing and producing antibodies and secreting various important chemicals. The antibodies mark cells infected with polio with a big sign that says “kill me”, and the soldiers of the immune system march in and do just that.
If it weren’t for your vaccine, the antibody response would have taken too long, and you would have become infected. Chances are you would get lucky and suffer nothing worse than a “stomach flu”. Or you could end up paralized.
So, when I read idiotic trash like the above article, I get really, really mad. All these years of science, medicine, and public health pumped into the sewer in favor of cult medicine bullshit. They should be ashamed. But of course, they have no shame.


Thanks! I became embroiled in vaccination woo here and here.
Before arguing back with the antivaccine woo-meisters I should have remembered the adage, “never wrestle with a pig — you both get dirty and the pig likes it.”
I decided to throw in the towel on this one: “I wonder why the pro-lifers haven’t jumped on the fact that many vaccines list the ingredient “human diploid cells” a.k.a aborted human fetal tissue.” Where to even start.
Anyway, thanks again for the Immune System for Beginners.
Yes, it is an interesting fringe argument. One of the vaccines is manufactured in a cell culture that originated from fetal tissue back in the 60s. The number of generations of cell cultures since then is…a lot. But you’re right, starting there doesn’t really help either.
Pal, I wouldn’t apologise for that simplification of the immune system if I were you- It was, to quote, “simple but not simplistic”. Excellent work!
The National Network for Immunization Information (NNii) has a good page on fetal cells and vaccines.
http://www.immunizationinfo.org/vaccine_components_detail.cfv?id=32
NNii seems to be a solid institution, from poking through its web pages, at least.
Do start collecting pre-vaccination anecdotes from your older patients, as you mentioned over at Terra Sigillata. I’ll be 57 this year, and I clearly remember the misery of the mumps, not to mention the classmates with braces and crutches from the effects of polio.
Of course, the hard-core anti-vaxxers (such as Mercola and his running mate Jock Doubleday) seem to be impervious to either reason or story.
To flesh out Liz’s comments for others, some pro-life/antivax nuts (especially AAPS, and other fringe groups) object to the “fetal” component of some vaccines (usually with hyperbolic language like “vaccines are made from aborted babies”).
The truth is available from her link above.
Great post. Though unrelated, I wish someone could explain to me why my immune system went postal on the beta cells in my pancreas, and I ended up with type 1 diabetes. I know it’s still a big unknown, it’s just a mystery I’d love to have the answer to. Of course, some of the woo-meisters probably think my childhood vaccinations caused it…
In the biography of Maurice Hilleman, http://www.amazon.com/Vaccinated-Defeat-Worlds-Deadliest-Diseases/dp/0061227951/ … there are some more details on the reasons and creation of the fetal cell lines, including the fact that when a pregnant woman came down with rubella many opted for abortion (and in the case of a co-worker’s wife in the early 1960s, it was because of fetal death).
Kathy,
Knowing what caused your autoimmune disorder will not correct or cure your autoimmune disorder or prevent other autoimmune disorders.
I stopped waiting for the scientific “cause” or “cure” for autoimmune disorders in our lifetime so don’t hold your breath, or your syringe, waiting.
You said you gave up!
I’m glad you’re so full of hope and cheer!
Actually, there has been a great deal of research into treatment and cure of various autoimmune diseases. One of the most dramatic and extreme is immune system destruction and reconstitution via stem cell transplantation. The field is quite exciting and advance have been tremendous. Anti-TNF antibodies and other treatments have revolutionized the field of inflammatory bowel disease, rheumatoid arthritis, and many others.
TI DM is still a ways off. Fortunately, treatment is quite good, but cure has been quite elusive. Research does teach us things, and it is likely we will know the cause/causes of TI DM in the forseeable future. That may not help Kathy directly, but I’m sure she cares about the future. A nihilist such as yourself is too self-absorbed to care about generations to come.
I pity you.
Nothing you have EVER mentioned has EVER helped ANY of my autoimmune disorders. The only thing the medical profession has ever provided is false promises of “cures” and “treatments” that were no better OR WORSE then what was already available (You are more than welcome to come to the East coast and pick up a cabinet full of EXUBERA if you want it). There is STILL no cure for IDDM. The only thing I have ever experienced over the decades from my experiences with the medical community is the false sense of security they attempt to provide their patients who would do better if they just took care of themselves. I pity most medical professional like you who just don’t seem to do very much for their patients other then continual “treatments”.
Oh, when I said I gave up, I meant that I gave up on believing promises of medical outcomes from medical professionals that haven’t proved their credibility to me.
I’m not sure what the Exubra comment is about. I don’t think i mentioned inhaled insulin products.
I’m sorry you’ve had such bad luck.
I don’t suggest mentioning inhaled insulin anytime soon. Exubera isn’t sold anymore. Few doctors prescribed it and it probably would have increased some respiratory problems since you needed to be checked every 6 months.
Chuck, if you have such a negative view of doctors and the medical community, why are you hanging out on a medical blog? It is probably just making you feel worse.
Kathy, if I may hazard a guess as to what causes the autoimmune ablation of the beta cells (but this is just speculation). I think it might be a “feature”. Losing your beta cells is bad, but having too many beta cells that are too active is worse. Too much insulin will put you into insulin shock and kill you in minutes (as opposed to weeks or months for diabetes). I suspect that ablation of the beta cells might be a protective “feature” to get rid of them when there are too many, or when some are too active, or when one has an insulin releasing tumor. I think it is only when that ablation is carried on for too long, the pancreas becomes inflamed which exacerbates the autoimmune sensitization and eventually kills off all of the beta cells. Then people notice that they have diabetes. But by then it is too late.
One of the things that regulates the immune system is nitric oxide, and if NO is too low, then the “gain” on the immune system is higher and all sorts of autoimmune things can happen. Diabetes might be one of them. It might be the ultimate “emergency insulin stopping mechanism” that is activated inappropriately because NO is too low.
Diabetes is rare in the rural undeveloped world. One reason might be increased NO levels from the bacteria I am studying which I think is the agent of the hygiene hypothesis the other reason might be the burden of intestinal and other parasites that people in the rural undeveloped world carry. Chronic parasite infestation causes expression of iNOS and increases systemic NO levels (but there are other effects as well). Some parasites do seem to be protective against asthma (I linked to a paper to that effect in another thread (more to pull PalMD’s chain and suggest he acquire some to ameliorate his asthma “naturally” as shown to be effective via EBM). They would likely be protective against autoimmune things like diabetes too. But once the sensitization of diabetes occurs, it is likely too late to do anything about it. Gut worms do help against Crohn’s Disease.
As much as I enjoy Chuck’s trolling, he left a fairly creepy comment that, unfortunately I had to delete. I may have to actually add him to my spam list after that one. Sorry, I hate to do it, but if the creepy factor gets too high, it’s necessary.
I like your rundown of the immune system you should submit that to mcgraw hill or whoever it is that publishes textbooks. that’s probably a good introduction for a 6-8th grade life science class, wouldn’t you think?
and daedalus, Crohn’s *may* be helped by gut worms. Then again, worms in your gut do more than just help with crohn’s, they can cause other issues. Crohn’s sounds like a nasty disease, my roommate had it, and we almost had to take him to the emergency room a few times.
And asthma being helped by parasites? Is this asthma that can’t be controlled by a breathing device once per week, controlled doses of Albuterol (or whatever the latest drug is), and a prescribed asthma pill?
Asthma sucks, i’ll admit. but most of the treatments work fairly well (at least from my observations of people with various severities of asthma… including myself.)
So many diseases, so much NASCAR. What’s the world to do?
That article is, to be blunt bucking fullshit. I grew up in 1970′s England, I know for a fact that the polio vaccine was in use then because I was GIVEN it.
What parent in their right mind would NOT vaccinate their child? My kids were unlucky enough to get Chickenpox before the vaccine became widely available, and seeing them suffer through it was awful for their dad and I. If someone had said to me ‘we can vaccinate them against it’ I’d have been all over it. ALL over it. So, how any parent can NOT vaccinate their child, preferring instead to literally jeoparidze their health and even their ability to procreate (mumps) is just beyond me.
You’ve got to be pretty fucking out there to risk your children’s lives for your own dumbass, ill-informed non-scientifitcally-based principles.
The Crohn’s study I was referring to is this:
http://gut.bmj.com/cgi/content/full/54/1/87
The asthma study is this:
http://ajrccm.atsjournals.org/cgi/content/full/174/5/514
The immune system (as all evolved systems) are a hodge-podge of trade-offs. A strong immune response is good, but anaphylaxis at every exposure to antigens is bad. The modern environment with abundant clean water and food is very different than the conditions that humans and human ancestors evolved over the past few hundred million years.
The worms used in the Crohn’s study don’t actually produce a long term infection in humans. They do in pigs. They probably don’t have much of a side effect (other than the creepy-crawly icky factor).
One of the reasons I bring them up is that I think the bacteria I am working with would provide some of the same benefits but with essentially no risk of adverse effects. Bacteria do have a creepy-crawly icky factor too, but (at least to me), it should be a lot less than gut worms, even for gut worms that can’t cause a long term infestation. There has been some progress, people are recognizing that some bacteria are necessary in the gut, and many people consume hundreds of grams a day of bacteria (as yogurt). Humans typically have a biomass of about 1.5 kg of bacteria in their gut. Virtually all of those bacteria actually can cause disease if they get into the “wrong” tissue compartment. The bacteria I am working with can’t (as far as I know) because they have no virulence factors and are incapable of deriving sustenance by metabolizing animal tissues (unlike the bacteria in yogurt).
I appreciate that my standards of what is a creepy-crawly icky factor may not be shared by everyone, even by those who strive for evidence based medicine.
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